Thesis
Fall 2025 · Active
The scientific discovery engine.
Location: San Francisco, US
Founded: 2025
Team size: 2
Industries:
About
Thesis is building the engine for scientific discovery. Our aim is to help researchers uncover the next AlphaFold or build the next Transformer, faster, more systematically, and at scale. We treat discovery not as a matter of luck, but as an engineering challenge to be solved. The mission is to democratize invention by empowering researchers everywhere with machine intelligence to drive the discovery of the next big thing.
Founders
Sergio CharlesFounder
Thesis will become the engine for all future scientific discovery. Maximally truth-seeking. Prev: AI R&D at Google X, Nvidia and Stanford's AI Lab, working with Andrew Ng and Chelsea Finn. B.S. Math & CS, M.S. Stats Stanford
Luigi CharlesFounder
Betting the farm that AI will become meaningful in the discovery of new science. Second time founder. Previously co-founded Sphere. Scaled its fintech rails from zero to billions in annual global payments volume and a $100M+ valuation. BS. Columbia Math & CS. All in. Zero hedge. Thesis is inevitable.